柳克银 研究员

邮箱：keyin_liu@shu.edu.cn

上海大学微电子学院

导师介绍：

主要研究方向为生物技术与信息技术融合（BTIT）领域，以面向临床重大需求、解决临床关键问题为核心，开展丝素蛋白材料及微电子技术融合研究。先后主持包括国家工信部生物医用材料揭榜挂帅（第二批）项目、国家自然基金面上项目及青年项目、上海市自然基金等。发表SCI/EI学术论文40余篇，申请专利50余项，并获授权专利26项。参与制定国家行业标准《组织工程医疗器械-丝素蛋白》（国际首项丝素蛋白材料行业标准，YY/T 1950-2024），牵头立项《外科植入物用丝素蛋白硬质材料》团体标准（中国生物医学工程学会）。入选上海市东方英才（青年），中国科学院青年创新促进会会员，国家药监局“丝素蛋白监管科学”项目专家。

招收微电子、机械工程、生物医学工程、材料及化学等相关专业背景的研究生。

研究方向：

可植入&可吸收生物传感器、丝素蛋白生物医用材料、植入式医疗器械产品

教育背景：

2010.09-2015.07，西安交通大学，仪器科学与技术，硕博连读

2006.09-2010.07，西安交通大学，机械工程及自动化，本科

工作经历：

2025.06-至 今，上海大学，研究员

2019.01-至 今，江西/上海丝科生物科技有限公司，CTO

2020.01-2025.05，中国科学院上海微系统与信息技术研究所，副研究员

2021.12-2022.12, 中国科学院上海分院, 科技发展部，科技挂职

2015.07-2019.12，中国科学院上海微系统与信息技术研究所，助理研究员

科研成果及获奖情况：

基于丝素蛋白材料及微电子融合技术，开发多类型创新生物医用材料、植入式传感器及高适应性神经接口，并在创伤外科、脊柱外科、神经外科、口腔科和整复外科等开展应用研究。先后获得2017西安交通大学优秀博士学位论文、2017陕西省优秀博士学位论文，并获得2014教育部科学技术二等奖（排名第7）、2023“中知路”长三角高价值专利运营大赛金奖、2024上海市“海聚英才”创新创业大赛总决赛优胜奖、2024医用蚕丝科技与生物材料转化大会最佳口头报告奖、2024第二十八届全国发明展览会“一带一路”暨金砖国家技能发展与技术创新大赛金奖等。

近五年代表性论文：

[1]Wengang Dong, Zhiheng Gao, Haoyuan Li, Siyuan Ni, Yating Xie, Ziyi Zhu, Tiger H. Tao,* Zhifeng Shi,* Yafei Feng,* and Keyin Liu*, Silk-Based Dura Mater Substitutes Featuring Tunable Tissue Integration and Anti-Infective Properties for Neurosurgical Applications, ACS Applied Materials & Interfaces, 2025, 17(36).

[2]Huiran Yang, Ziyi Zhu, Siyuan Ni, et al, Keyin Liu*, and Xiaoling Wei*, Silk fibroin-based bioelectronic devices for high-sensitivity, stable, and prolonged in vivo recording, Biosensors and Bioelectronics, 2025, 267, 116853.

[3]Ziyi Zhu, Zhiwen Yan, Siyuan Ni, Huiran Yang, Yating Xie, Xueying Wang, Dujuan Zou, Chen Tao, Cunyi Fan, Tiger H. Tao, Xiaoling Wei*,Yun Qian*, and Keyin Liu*, Tissue/Organ Adaptable Bioelectronic Silk-Based Implants, Advanced Materials, 2024, 36(38).

[4]Yating Xie, Lele Geng, Siyuan Ni, et al, Keyin Liu*, and Yinbo Peng*, Water-Responsive Self-Contractive Silk-Based Skin Anti-Aging Tensioners with Customizable Biofunctions, Advanced Healthcare Materials, 2024, 13(26). 封面文章

[5]Wenze Chen #, Keyin Liu #, Xiaoyu Liao, et al, Harmonizing Thickness and Permeability in Bone Tissue Engineering: A Novel Silk Fibroin Membrane Inspired by Spider Silk Dynamics, Advanced Materiasl, 2023, 36(13). 封面文章

[6]Tianji Wang #, Keyin Liu #, Jing Wang, et al, Spatiotemporal Regulation of Injectable Heterogeneous Silk Gel Scaffolds for Accelerating Guided Vertebral Repair, Advanced Healthcare Materials, 2023, 12(7). 封面文章

[7]Hao Bai, Siqi Zhang, Huiran Yang, et al, Keyin Liu*, Wei Lei*, Tiger H. Tao*, and Yafei Feng*, Advanced nerve regeneration enabled by neural conformal electronic stimulators enhancing mitochondrial transport, Bioactive Materials, 2024, 39, 287–301. 封面文章

[8]Xiang Geng#, Liu Keyin#, Wang Tianji, Hu Xiaofan, Wang Jing, Gao Zhiheng, Lei Wei, Feng Yafei*, Tao Tiger H*; In Situ Regulation of Macrophage Polarization to Enhance Osseointegra tion Under Diabetic Conditions Using Injectable Silk/Sitagliptin Gel Scaffolds, Advanced Science, 2021, 8(3): 0-200232. 封面文章

[9]Mengwei Liu, Yujia Zhang, Keyin Liu, Gai Zhang, Ying Mao, Liang Chen*, Yinbo Peng*, Tiger H. Tao*, Biomimicking Antibacterial Opto-Electro Sensing Sutures Made of Regenerated Silk Proteins, Advanced Materials, 2021, 33: 2004733. 封面文章

[10]Liu Keyin#, Fan Zhen#, Wang Tianji#, Gao Zhiheng, Zhong Junjie, Xiang Geng; Lei Wei, Shi Zhifeng, Feng Yafei, Mao Ying*, Tao Tiger H*, All-Aqueous-Processed Injectable In Situ Forming Macroporous Silk Gel Scaffolds for Minimally Invasive Intracranial and Osteological Therapies, Advanced Healthcare Materials, 2020, 9(16): 0-2000879. 封面文章

[11]Lee Woonsoo, Zhou Zhitao, Chen Xinzhong, Qin Nan, Jiang Jianjuan, Liu Keyin, Liu Mengkun*, Tao Tiger H. *, Li Wei*, A rewritable optical storage medium of silk proteins using nearfield nano-optics, Nature Nanotechnology, 2020, 15(11): 941-947.

[12]Ziyi Zhu,  Zhiwen Yan, Huiran Yang, Xueying Wang, Siyuan Ni, Dujuan Zou, Keyin Liu*, Tiger H. Tao, "Implantable Electrode Based on Pre-Stretched Silk Film for in Vivo Application," 2024 IEEE 37th International Conference on Micro Electro Mechanical Systems (MEMS), Austin, TX, USA, 2024, pp. 396-399, doi: 10.1109/MEMS58180.2024.10439580.

[13]Huiran Yang, Ziyi Zhu, Xueying Wang, Dujuan Zou, Wanqi Jiang, Zhitao Zhou, Liuyang Sun, Keyin Liu*, Tiger H. Tao*, Xiaoling Wei*, "Oriented Crystallization Silk-Based Electronic Interface Towards Chronical Recording," 2024 IEEE 37th International Conference on Micro Electro Mechanical Systems (MEMS), Austin, TX, USA, 2024, pp. 445-448, doi: 10.1109/MEMS58180.2024.10439410.

[14]Z. Wang, K. Liu, N. Qin and T. H. Tao, "A Silk-Based Microneedle Patch for Controlled Multi-Drug Delivery in Glioma Treatment," 2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), Orlando, FL, USA, 2021, pp. 1416-1419, doi: 10.1109/Transducers50396.2021.9495404.

[15]Y. Xie, K. Liu* and T. H. Tao*, "Biofunctional and Self-Contractable Silk-Based Sensing Threads," 2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), Orlando, FL, USA, 2021, pp. 491-494, doi: 10.1109/Transducers50396.2021.9495408.

[16]Z. Gao, T. H. Tao * and K. Liu*, "Biomimic Antibacterial Sensing Silk Bio-Patch," 2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), Orlando, FL, USA, 2021, pp. 1420-1423, doi: 10.1109/Transducers50396.2021.9495518.

[17]Zhitao Zhou, Woonsoo Lee, Xinzhong Chen, Nan Qin, Jianjuan Jiang, Keyin Liu, Mengkun Liu, Tiger H. Tao, "Rewritable Optical Storage Medium of Silk Proteins Using Tip-Based Nanolithography," 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS), Gainesville, FL, USA, 2021, pp. 63-66, doi: 10.1109/MEMS51782.2021.9375408.

[18]Z. Gao, S. Li, F. Chen, Y. Hua, T. H. Tao * and K. Liu*, "3D Silk-Based Bioelectronic Scaffolds for Osteochondral Regeneration," 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS), Vancouver, BC, Canada, 2020, pp. 437-439, doi: 10.1109/MEMS46641.2020.9056220.